Subscribers will initially get more than 500 movies and 7,500 TV episodes. That's expected to grow to 620 movies and 10,000 episodes in five years, as existing deals with rival streaming services expire.
The service will cost $7 a month, or $70 for the year if paid up front. Four people can stream simultaneously on a single subscription. Disney Plus is also offering downloads for offline viewing on up to 10 devices.
Here's a look at what will be available at launch:
ORIGINALS
"The Mandalorian" Star Wars series, about a bounty hunter from the same planet as Boba Fett. First episode on Tuesday, with a new episode every Friday.
"High School Musical: The Musical: The Series," a mockumentary about a high school musical, with episodes airing weekly.
Live-action version of the Disney animated classic "Lady and the Tramp."
"Noelle," a holiday movie starring Anna Kendrick and Bill Hader.
Documentary series "Encore!" reuniting high school musical casts to perform their shows again, featuring Kristen Bell.
Documentary series about Disney called "The Imagineering Story."
"The World According to Jeff Goldblum," in which the actor tackles different topics like sneakers and tattoos.
"Marvel's Hero Project" a nonfiction series about kids who perform community service.
Pixar animated short film series "Forky Asks a Question," about a character from "Toy Story 4," and SparkShorts, Pixar's animated short film program.
FROM THE VAULT
Disney's movie classics such as "Cinderella," ''Snow White and the Seven Dwarfs," ''Pinocchio," ''Swiss Family Robinson" and "Fantasia."
PIXAR
The majority of the 21 Pixar movies will be on the service. Disney Plus won't launch with a few, including "Coco," and "Toy Story 4," but all of them should be available within the first year.
FOX
Past 30 seasons of "The Simpsons."
Two X-Men movies, "X-Men: Evolution" and "Wolverine and the X-Men."
Other Fox movies such as "Avatar," ''Home Alone" and "Miracle on 34th Street."
MARVEL
Eight movies initially: "Avengers: Endgame," ''Avengers: Age of Ultron," ''Iron Man," ''Iron Man 3," ''Captain Marvel," ''Thor: The Dark World," ''Guardians of the Galaxy" and "Ant-Man"
STAR WARS
The first two trilogies: "The Phantom Menace," ''Attack of the Clones," ''Revenge of the Sith," ''A New Hope," ''The Empire Strikes Back," ''Return of the Jedi."
Two newer entrants: "The Force Awakens" and "Rogue One."
NATIONAL GEOGRAPHIC
The full library including shows such as "Wild Yellowstone," ''Kingdom of the White Wolf" and "Gordon Ramsay: Uncharted."
NOT YET
Some movies and shows will await expiration of existing streaming deals with rivals. The Pixar cartoon "Coco," the live-action "Beauty and the Beast" and the Star Wars movies "The Last Jedi" and "Solo" fall in this category.
Others like "Maleficent: Mistress of Evil" and "The Lion King" remake haven't been released for streaming yet. "Maleficent" is still in theaters.
Other original TV shows like Marvel's "Loki" are still in the works.