President Abdul Hamid, the chancellor of the university, will attend the convocation while Finance Minister AHM Mustafa Kamal will deliver the convocation speech.
Deputy Minister of Education Mohibul Hasan Chowdhury and University Grants Commission (UGC) Chairman Dr Kazi Shahidullah will be present as special guests.
In the build up to the occasion, academic and administrative buildings, residential halls, and the main entrance gate have been decorated with lights.
Altogether 2,888 graduates are scheduled to attend the convocation while 14 students among them will be awarded gold medals, said university sources.
Comilla University was established in 2006 as the 26th public university of the country with seven functional departments.
Now there are 19 departments where 253 teachers are teaching 7,055 students, according to the university website.