Chief Art Acevedo says the suspects were killed after firing at officers serving a search warrant at a southeast Houston home where authorities allege black tar heroin was being sold.
Four of the officers were shot and a fifth suffered a knee injury.
Acevedo says two of the officers who were shot were hit in the neck by gunfire and are in critical but stable condition.
The other three officers are in stable condition and are expected to make a full recovery.
Acevedo didn't immediately have additional information about the suspects.
Acevedo says the officers came under fire just after forcing open the home's front door.
The head of the union for Houston police officers says the five officers injured in a shooting are in critical and stable condition.
Joe Gamaldi, president of the Houston Police Officers' Union, says in a tweet that two officers are in critical condition and the other three are in stable condition.
The officers were taken to Memorial Hermann-Texas Medical Center in Houston.
Gamaldi says one of the injured officers was taken to the hospital by helicopter.
Houston police say in a tweet that a suspect is dead at the scene.
Police say the officers were injured "following an encounter with a suspect" Monday afternoon in a neighborhood in southeast Houston.
Houston Police Chief Art Acevedo and Mayor Sylvester Turner were scheduled to hold a news conference on the shooting Monday evening.
Texas Gov. Greg Abbott has pledged any state resources needed for Houston police "to bring swift justice to those involved" in the shooting of five Houston police officers.
The five were shot and wounded during an encounter with a suspect Monday afternoon in a southeast Houston neighborhood. All five were taken to a Houston hospital but their conditions haven't been released.
In a statement, Abbott called the attack "horrific" and "a solemn reminder of the service and sacrifice" law enforcement officers make daily.
Mayor Sylvester Turner tweeted that one suspect "is down." Aerial video showed police tactical squad resources have been deployed outside the house where the shooting happened.
Houston police say five officers have been struck in a shooting and have been taken to a local hospital.
In a tweet, Houston police say the officers were "struck with gunfire following an encounter with a suspect" Monday afternoon in a neighborhood in southeast Houston.
Mayor Sylvester Turner tweeted that the suspect "is down." Additional information on the suspect was not immediately available.
Turner was seen Monday evening entering the hospital where the injured officers were taken.
Their conditions were not immediately known.
Joe Gamaldi, president of the Houston Police Officers' Union, says one of the injured officers was taken to the hospital by helicopter.
Officials say at least three Houston police officers have been wounded in a shooting.
In a tweet, Houston police say the officers were "struck with gunfire following an encounter with a suspect" Monday afternoon in a neighborhood in southeast Houston.
Mayor Sylvester Turner tweeted that the suspect "is down" and at least three officers have been injured.
Police say the officers are being transported to a hospital. Their conditions were not immediately known.
Joe Gamaldi, president of the Houston Police Officers' Union, says one of the injured officers was taken to a hospital by helicopter.