The doors of jihad opened for Ayman al-Zawahri as a young doctor in a Cairo clinic, when a visitor arrived with a tempting offer: a chance to treat Islamic fighters battling Soviet forces in Afghanistan.

With that offer in 1980, al-Zawahri embarked on a life that over three decades took him to the top of the most feared terrorist group in the world, al-Qaida, after the death of Osama bin Laden.

Already an experienced militant who had sought the overthrow of Egypt’s “infidel” regime since the age of 15, al-Zawahri took a trip to the Afghan war zone that was just a few weeks long, but it opened his eyes to new possibilities.

What he saw was “the training course preparing Muslim mujahedeen youth to launch their upcoming battle with the great power that would rule the world: America,” he wrote in a 2001 biography-cum-manifesto.

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Al-Zawahri, 71, was killed over the weekend by a U.S. drone strike in Afghanistan. President Joe Biden announced the death Monday evening.

The strike is likely to lead to greater disarray within the organization than did bin Laden’s death in 2011, since it is far less clear who his successor would be.

Al-Zawahri was crucial in turning the jihadi movement to target the United States as the right-hand man to bin Laden, the young Saudi millionaire he met in the Afghanistan-Pakistan region. Under their leadership, the al-Qaida terror network carried out the deadliest attack ever on American soil, the Sept. 11, 2001, suicide hijackings.

The attacks on the World Trade Center and Pentagon made bin Laden America’s Enemy No. 1. But he likely could never have carried it out without his deputy.

While bin Laden came from a privileged background in a prominent Saudi family, al-Zawahri had the experience of an underground revolutionary. Bin Laden provided al-Qaida with charisma and money, but al-Zawahri brought tactics and organizational skills needed to forge militants into a network of cells in countries around the world.

“Bin Laden always looked up to him,” said terrorism expert Bruce Hoffman of Georgetown University.

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When the 2001 U.S. invasion of Afghanistan demolished al-Qaida’s safe haven and scattered, killed and captured its members, al-Zawahri ensured al-Qaida’s survival. He rebuilt its leadership in the Afghan-Pakistan border region and installed allies as lieutenants in key positions.

He also became the movement’s public face, putting out a constant stream of video messages while bin Laden largely hid.

With his thick beard, heavy-rimmed glasses and a prominent bruise on his forehead from prostration in prayer, he was notoriously prickly and pedantic. He picked ideological fights with critics within the jihadi camp, wagging his finger scoldingly in his videos. Even some key figures in al-Qaida’s central leadership were put off, calling him overly controlling, secretive and divisive — a contrast to bin Laden, whose soft-spoken presence many militants described in adoring, almost spiritual terms.

Yet he reshaped the organization from a centralized planner of terror attacks into the head of a franchise chain. He led the creation of a network of autonomous branches around the region, including in Iraq, Saudi Arabia, Yemen, North Africa, Somalia and Asia.

In the decade after 9/11, al-Qaida inspired or had a direct hand in attacks in all those areas as well as Europe, Pakistan and Turkey, including the 2004 train bombings in Madrid and the 2005 transit bombings in London. More recently, the al-Qaida affiliate in Yemen has proven itself capable of plotting attacks on U.S. soil with an attempted 2009 bombing of an American passenger jet and an attempted package bomb the following year.

After Bin Laden was killed in a U.S. raid on his compound in Abbottabad, Pakistan, al-Qaida proclaimed al-Zawahri its paramount leader less than two months later.

The jihad against America “does not halt with the death of a commander or leader,” he said.

The 2011 Arab Spring uprisings around the Mideast threatened a major blow to al-Qaida, showing that jihad was not the only way to get rid of Arab autocrats. It was mainly pro-democracy liberals and leftists who led the uprising that toppled Egypt’s President Hosni Mubarak, the longtime goal al-Zawahri failed to achieve.

But al-Zawahri sought to co-opt the wave of uprisings, insisting that they would have been impossible if the 9/11 attacks had not weakened America. And he urged Islamic hard-liners to take over in the nations where leaders had fallen.

Al-Zawahri was born June 19, 1951, the son of an upper-middle-class family of doctors and scholars in the Cairo suburb of Maadi.

From an early age, he was enflamed by the radical writings of Sayed Qutb, the Egyptian Islamist who taught that Arab regimes were “infidel” and should be replaced by Islamic rule.

In the 1970s, as he earned his medical degree as a surgeon, he was active in militant circles. He merged his own militant cell with others to form the group Islamic Jihad and began trying to infiltrate the military — at one point even storing weapons in his private clinic.

Then came the 1981 assassination of Egyptian President Anwar Sadat by Islamic Jihad militants. The slaying was carried out by a different cell in the group — and al-Zawahri has written that he learned of the plot only hours before the assassination. But he was arrested along with hundreds of other militants and served three years in prison.

After his release in 1984, al-Zawahri returned to Afghanistan and joined the Arab militants from across the Middle East fighting alongside the Afghans against the Soviets. He courted bin Laden, who became a heroic figure for his financial support of the mujahedeen.

Al-Zawahri followed bin Laden to his new base in Sudan, and from there he led a reassembled Islamic Jihad group in a violent campaign of bombings aimed at toppling Egypt’s U.S.-allied government.

The Egyptian movement failed. But al-Zawahri would bring to al-Qaida the tactics that he honed in Islamic Jihad.

He promoted the use of suicide bombings, to become al-Qaida’s hallmark. He plotted a 1995 suicide car bombing of Egypt’s embassy in Islamabad that killed 16 people — presaging the more devastating 1998 al-Qaida bombings of the U.S. embassies in Kenya and Tanzania that killed more than 200, attacks al-Zawahri was indicted for in the United States.

In 1996, Sudan expelled bin Laden, who took his fighters back to Afghanistan, where they found a safe haven under the radical Taliban regime. Once more, al-Zawahri followed.