U.S. Secretary of State Antony Blinken said Thursday a major Israeli ground assault on the southern Gaza town of Rafah would be “a mistake” and “unnecessary” to defeating Hamas, underscoring the further souring of relations between the United States and Israel.

Blinken, on his sixth urgent Mideast mission since the war began in October, spoke after huddling with top Arab diplomats in Cairo for discussions on efforts for a cease-fire and Gaza's post-conflict future. He said an “immediate, sustained cease-fire” with the release of Israeli hostages held by Hamas was urgently needed and that gaps were narrowing in indirect negotiations that U.S., Egypt and Qatar have spent weeks mediating. Those negotiations are to continue at a senior level in Qatar on Friday.

Heavy fighting rages around Gaza's biggest hospital as Israel raids it for a second day

Blinken heads to Israel on Friday to meet Prime Minister Benjamin Netanyahu and his War Cabinet. The growing disagreements between Netanyahu and President Joe Biden over the prosecution of the war will likely overshadow those talks — particularly over Netanyahu's determination to launch a ground assault on Rafah, where more than a million Palestinians have sought refuge from devastating Israeli ground and air strikes further north.

Netanyahu has said that without an invasion of Rafah, Israel can't achieve its goal of destroying Hamas after its deadly Oct. 7 attack and taking of hostages that triggered Israel's bombardment and offensive in Gaza.

Egypt appeals for more aid deliveries by land to Gaza as Israel warns of Rafah push

“A major military operation in Rafah would be a mistake, something we don’t support. And, it’s also not necessary to deal with Hamas, which is necessary,” Blinken told a news conference in Cairo with Egyptian Foreign Minister Sameh Shoukry. A major offensive would mean more civilian deaths and worsen Gaza's humanitarian crisis, Blinken said, adding that his talks on Rafah in Israel on Friday and discussions between senior U.S. and Israeli officials next week in Washington will be to share ideas for alternative action.

Israel wants Rafah civilians to go to Gaza's center ahead of southern offensive

The U.S. position on a Rafah operation has shifted significantly in recent days. Initially, U.S. officials said they could not support a major incursion into the city unless there was a clear and credible plan for getting civilians out of harm's way. Now, U.S. officials said they have concluded there is no credible way to do that, given the density of the population of more than a million people. They say now that other options, including specifically targeted operations against known Hamas fighters and commanders, are the only way to avoid a civilian catastrophe.

But Netanyahu, on a roughly 45-minute call with GOP senators on Wednesday, pledged to ignore warnings about a Rafah operation. He also took aim at Senate Majority Leader Chuck Schumer’s condemnation last week of the civilian death toll in Gaza and his call for new elections in Israel in a speech that Biden later said was “good.”

Netanyahu stressed that Israel would move ahead in Rafah, according to senators who participated in the meeting. Sen. John Kennedy, a Louisiana Republican, said Netanyahu “made it very clear that he and the people of Israel intend to prosecute the war to the full extent of their power and that he would not be dictated to by Senator Schumer or President Biden.”

Netanyahu has been accused by Israeli critics of undermining bipartisan American support by cultivating close ties with Republican leaders.

As Blinken and the Arab ministers met, Gaza’s Health Ministry raised the territory’s death toll to nearly 32,000 Palestinians since the war began on its soil. Also, U.N. officials stepped up warnings that famine is “imminent” in northern Gaza.

The Cairo talks gathered Blinken with the foreign ministers of Egypt, Jordan, Qatar, Saudi Arabia, and the United Arab Emirates, as well as a top official from the Palestine Liberation Organization, the internationally recognized body representing the Palestinian people. They also discussed ways to increase urgent humanitarian aid deliveries to Gaza by land, air and sea.

In an earlier meeting with Blinken, Egyptian President Abdel Fattah el-Sissi stressed the need for an immediate cease-fire and warned against the “dangerous repercussions” of any Israeli offensive in Rafah, according to a statement issued by el-Sissi’s spokesperson.

Both parties renewed their rejection of the forced displacement of Gazans and agreed on the importance of taking all necessary measures to ensure the arrival of humanitarian aid into the Gaza Strip, the statement said.

Blinken said “gaps are narrowing” in talks over a cease-fire but that more work was needed. “There are still real challenges,” he said. "We’ve closed some gaps but there are still gaps.”

Netanyahu’s office said Thursday that the head of the Mossad spy agency will return to Qatar on Friday to meet with CIA chief William Burns and other key mediators in the talks. The office said Thursday that Qatar’s prime minister and Egypt’s intelligence chief would also join the talks.

Meanwhile, the United States said it would seek a vote Friday on a revised and tougher U.N. resolution demanding “an immediate and sustained cease-fire” to protect civilians and enable humanitarian aid to be delivered. The resolution is notable because it does not directly tie the release of the hostages to the need for a cease-fire.

Still, Blinken said the two must go hand-in-hand. “There is an urgent need for an immediate, sustained cease-fire with the release of hostages,” he said.

Netanyahu has also rejected the Biden administration's repeated remonstrations that Israel's long-term security cannot be assured without the creation of an independent Palestinian state.

A clear path and deadline for the formation of a Palestinian state are key requirements for Saudi Arabia and other Arab nations to normalize relations with Israel, something Netanyahu is keen to achieve. Blinken spent much of his time in Jeddah with Saudi Crown Prince Mohammed bin Salman discussing the normalization process, which would also include U.S.-Saudi agreements.

With tensions running high after not speaking for a month, Biden and Netanyahu held a phone call on Monday during which Netanyahu agreed to send a team of experts to Washington to discuss the Rafah plans. Israeli Defense Minister Yoav Gallant will also visit Washington separately next week.

The war began after Palestinian militants killed some 1,200 people in the surprise Oct. 7 attack out of Gaza that triggered the war, and abducted another 250 people. Hamas is still believed to be holding some 100 people hostage, as well as the remains of 30 others.