South Africa were in sight of a series victory Sunday as Bangladesh stumbled to 27-3 chasing 413 to win the second Test.
South Africa forced out Mahmudul Hasan Joy (0), Najmul Hossain Shanto (7) and Tamim Iqbal (13) in 9.1 overs of the Bangladesh second innings before stumps were called on the third day in Gqeberha.
Bangladesh need another 386 runs and their overall target is only five runs short of the world record for a successful fourth-innings run chase.
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The tourists would have to make far more than the highest fourth innings total ever at St George's Park, which stands at 281.
South Africa's spinners again came through late in the day, with Keshav Maharaj claiming two of the wickets and Simon Harmer one to leave Bangladesh in deep trouble with two days of the Test remaining.
South Africa lead the two-test series 1-0 after a 220-run win in the first match.
The Proteas dismissed Bangladesh for 217 in their first innings earlier in the day and then the hosts made 176-6 declared in their second innings to set the huge target.
Those runs came in 39.5 overs, with opener Sarel Erwee hitting 41 and Kyle Verreynne making 39 not out in the middle order.
It gave the Proteas enough time to put the Tigers back in near the end of the day.
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There was a worrying moment at the very start of South Africa's second innings when Erwee hit a powerful shot off the back foot straight at fielder Mehidy Hasan Miraz at backward point.
Mehidy lost sight of the ball completely and was turning his head to his left believing it had gone past him when it hit him square in the chest. He left on a stretcher but returned to the field later and appeared to have sustained no serious injury.
South Africa batter Temba Bavuma and Bangladesh fast bowler Khaled Ahmed were also involved in a strange incident that left both hurting.
Bavuma was not watching where he was going and ran straight into Khaled, with his helmet crashing into the bowler's outstretched left arm. They both grimaced in pain and had treatment but played on.