The number of people sent fleeing Ukraine by Russia’s invasion topped 1 million on Wednesday, the swiftest refugee exodus this century, the United Nations said, as Russian forces kept up their bombardment of the country’s second-biggest city, Kharkiv, and laid siege to two strategic seaports. The tally from the U.N. refugee agency released to The Associated Press amounts to more than 2 percent of Ukraine’s population being forced out of the country in less than a week. The mass evacuation could be seen in Kharkiv, where residents desperate to get away from falling shells and bombs crowded the city’s train station and tried to press onto trains, not always knowing where they were headed. In a videotaped address, Ukrainian President Volodymyr Zelenskyy called on Ukrainians to keep up the resistance. He vowed that the invaders would have “not one quiet moment” and described Russian soldiers as “confused children who have been used.” Moscow’s isolation deepened when most of the world lined up against it at the United Nations to demand it withdraw from Ukraine. And the prosecutor for the International Criminal Court opened an investigation into possible war crimes. With fighting going on on multiple fronts across the country, Britain’s Defense Ministry said Mariupol, a large city on the Azov Sea, was encircled by Russian forces, while the status of another vital port, Kherson, a Black Sea shipbuilding city of 280,000, remained unclear. Russian President Vladimir Putin’s forces claimed to have taken complete control of Kherson, which would make it the biggest city to fall yet in the invasion. But a senior U.S. defense official disputed that. READ: As Russia batters Ukraine, both sides ready for more talks “Our view is that Kherson is very much a contested city,” the official said, speaking on condition of anonymity. Zelenskyy’s office told the AP that it could not comment on the situation in Kherson while the fighting was still going on. But the mayor of Kherson, Igor Kolykhaev, said Russian soldiers were in the city and came to the city administration building. He said he asked them not to shoot civilians and to allow crews to gather up the bodies from the streets. “I simply asked them not to shoot at people,” he said in a statement. “We don’t have any Ukrainian forces in the city, only civilians and people here who want to LIVE.” Mariupol Mayor Vadym Boychenko said the attacks there had been relentless. READ: Russia-Ukraine conflict: BGMEA sees challenges for trade “We cannot even take the wounded from the streets, from houses and apartments today, since the shelling does not stop,” he was quoted by the Interfax news agency as saying. Russia reported its military casualties for the first time since the invasion began last week, saying nearly 500 of its troops have been killed and almost 1,600 wounded. Ukraine did not disclose its own military losses but said more than 2,000 civilians have died, a claim that could not be independently verified. In a video address to the nation early Thursday, Zelenskyy praised his country’s resistance. “We are a people who in a week have destroyed the plans of the enemy,” he said. “They will have no peace here. They will have no food. They will have here not one quiet moment.” He said the fighting is taking a toll on the morale of Russian soldiers, who “go into grocery stores and try to find something to eat.” “These are not warriors of a superpower,” he said. “These are confused children who have been used.” Meanwhile, the senior U.S. defense official said an immense column of hundreds of tanks and other vehicles appeared to be stalled roughly 25 kilometers (16 miles) from Kyiv and had made no real progress in the last couple of days. The convoy, which earlier in the week had seemed poised to launch an assault on the capital, has been plagued with fuel and food shortages, the official said. Western officials warn that Russia’s far stronger military is likely to adapt quickly. On the far edges of Kyiv, volunteers well into their 60s manned a checkpoint to try to block the Russian advance. “In my old age, I had to take up arms,” said Andrey Goncharuk, 68. He said the fighters needed more weapons, but “we’ll kill the enemy and take their weapons.” Around Ukraine, others crowded into train stations, carrying children wrapped in blankets and dragging wheeled suitcases into new lives as refugees. In an email, U.N. refugee agency spokesperson Joung-ah Ghedini-Williams told the AP that the latest data indicates the refugee count surpassed 1 million as of midnight in central Europe, based on figures collected by national authorities. Shabia Mantoo, another spokesperson for the agency, said Wednesday that “at this rate” the exodus from Ukraine could make it the source of “the biggest refugee crisis this century.” A large explosion shook central Kyiv on Wednesday night in what the president’s office said was a missile strike near the capital city’s southern railway station. There was no immediate word on any deaths or injuries. Thousands of Ukrainians have been fleeing the city through the sprawling railway complex. Russian forces pounded Kharkiv, Ukraine’s biggest city after Kyiv, with about 1.5 million people, in another round of aerial attacks that shattered buildings and lit up the skyline with flames. At least 21 people were killed and 112 injured over the past day, said Oleg Sinehubov, head of the Kharkiv regional administration. Several Russian planes were shot down over Kharkiv, according to Oleksiy Arestovich, a top adviser to Zelenskyy. “Kharkiv today is the Stalingrad of the 21st century,” Arestovich said, invoking what is considered one of the most heroic episodes in Russian history, the five-month defense of the city from the Nazis during World War II. From his basement bunker, Kharkiv Mayor Igor Terekhov told the BBC: “The city is united and we shall stand fast.” Russian attacks, many with missiles, blew the roof off Kharkiv’s five-story regional police building and set the top floor on fire, and also hit the intelligence headquarters and a university building, according to officials and videos and photos released by Ukraine’s State Emergency Service. Officials said residential buildings were also hit, but gave no details. The head of the U.N. nuclear watchdog agency warned that the fighting poses a danger to Ukraine’s 15 nuclear reactors. Rafael Grossi of the International Atomic Energy Agency noted that the war is “the first time a military conflict is happening amid the facilities of a large, established nuclear power program,” and he said he is “gravely concerned.” Russia already has seized control of the decommissioned Chernobyl power plant, the scene in 1986 of the world’s worst nuclear disaster. In New York, the U.N. General Assembly voted to demand that Russia stop its offensive and immediately withdraw all troops, with world powers and tiny island states alike condemning Moscow. The vote was 141 to 5, with 35 abstentions. Assembly resolutions aren’t legally binding but can reflect and influence world opinion. The vote came after the 193-member assembly convened its first emergency session since 1997. The only countries to vote with Russia were Belarus, Syria, North Korea and Eritrea. Cuba spoke in Moscow’s defense but ultimately abstained. Ukraine’s U.N. Ambassador Sergiy Kyslytsya said Russian forces “have come to the Ukrainian soil, not only to kill some of us ... they have come to deprive Ukraine of the very right to exist.” He added: ”The crimes are so barbaric that it is difficult to comprehend.” Russia ramped up its rhetoric. Foreign Minister Sergei Lavrov reminded the world about the country’s vast nuclear arsenal when he said in an interview with Al-Jazeera that “a third world war could only be nuclear.” In the northern city of Chernihiv, two cruise missiles hit a hospital, according to the Ukrainian UNIAN news agency, which quoted the health administration chief, Serhiy Pivovar, as saying authorities were working to determine the casualty toll.